Підвищення ефективності електроретинографічної системи

Abstract

The article gives the rationale for the choice of a mathematical model of the response of the retina that is stimulated with the aid of beam of light of low-intensity, taking into account of the Weber- Fechner law. It has been established that the noise of the retina response and deviation from the norm of response of retina can be considered to be independent from the stimulation intensity. Moreover, their influence on response retina additively. The resolution of the measurements of deviations increasing significantly when intensity of stimulation is decreasing (by Weber- Fechner law). Since this significantly reduces signal to noise ratio, an optimal filtering of response of the retina requires. Reasoned decision for the choice of optimal filter structure found. Computer simulations for elektroretinosignal, electroretinogram and noise have been developed. The formula of probability of confidence (in sense of Borel) of study results has been determined for a given probability of their fallibility. It has been applied for estimation the effectiveness of elektroretinography system. The electroretinography with a low-intensity excitation will allow reaching neurotoxicity risk estimation at his initial stage. Algorithm for neurotoxicity assessment of a priori unknowns’ toxicants by electroretinography is given.

В роботі наведено обґрунтування вибору математичної моделі реакції сітківки, стимульованої за допомогою променя світла низької інтенсивності, з урахуванням закону Вебера-Фехнера. Встановлено, що електроретинографія з низькою Інтенсивністю дозволяє оцінити ризик нейротоксикації на її початковій стадії. Алгоритм оцінювання нейротоксикації апріорно невідомими токсикаптами за допомогою електроретинографії розроблено.